中文名稱：小鼠抗DLAT單克隆抗體

英文名稱： Anti-DLAT mouse monoclonal antibody

別名： dihydrolipoamide S-acetyltransferase; DLTA; PDCE2; PDC-E2

相關(guān)類別：一抗

儲(chǔ) 存：冷凍（-20℃）

宿主： Mouse

抗原： DLAT

反應(yīng)種屬： Human, Mouse

標(biāo) 記物： Unconjugate

克隆類型： Mouse Monoclonal

技術(shù)規(guī)格

Background:

This gene encodes component E2 of the multi-enzyme pyruvate dehydrogenase complex (PDC). PDC resides in the inner mitochondrial membrane and catalyzes the conversion of pyruvate to acetyl coenzyme A. The protein product of this gene, dihydrolipoamide acetyltransferase, accepts acetyl groups formed by the oxidative decarboxylation of pyruvate and transfers them to coenzyme A. Dihydrolipoamide acetyltransferase is the antigen for antimitochondrial antibodies. These autoantibodies are present in nearly 95% of patients with the autoimmune liver disease primary biliary cirrhosis (PBC). In PBC, activated T lymphocytes attack and destroy epithelial cells in the bile duct where this protein is abnormally distributed and overexpressed. PBC enventually leads to cirrhosis and liver failure. Mutations in this gene are also a cause of pyruvate dehydrogenase E2 deficiency which causes primary lactic acidosis in infancy and early childhood.

Applications:

WB, IF, IP

Name of antibody:

DLAT

Immunogen:

Fusion protein of human DLAT

Full name:

dihydrolipoamide S-acetyltransferase

Synonyms:

DLTA; PDCE2; PDC-E2

SwissProt:

P10515

WB Predicted band size:

69 kDa

WB Positive control:

Jurkat, A549, U251, F9, Lncap and Hela cell lysates

WB Recommended dilution:

1000-5000

IF positive control:

Hela cells

IF Recommend dilution:

150-300

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細(xì)胞系

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原代細(xì)胞

細(xì)胞專用培養(yǎng)基

菌株

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病理染色液

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小鼠抗DLAT單克隆抗體

Background:	This gene encodes component E2 of the multi-enzyme pyruvate dehydrogenase complex (PDC). PDC resides in the inner mitochondrial membrane and catalyzes the conversion of pyruvate to acetyl coenzyme A. The protein product of this gene, dihydrolipoamide acetyltransferase, accepts acetyl groups formed by the oxidative decarboxylation of pyruvate and transfers them to coenzyme A. Dihydrolipoamide acetyltransferase is the antigen for antimitochondrial antibodies. These autoantibodies are present in nearly 95% of patients with the autoimmune liver disease primary biliary cirrhosis (PBC). In PBC, activated T lymphocytes attack and destroy epithelial cells in the bile duct where this protein is abnormally distributed and overexpressed. PBC enventually leads to cirrhosis and liver failure. Mutations in this gene are also a cause of pyruvate dehydrogenase E2 deficiency which causes primary lactic acidosis in infancy and early childhood.
Applications:	WB, IF, IP
Name of antibody:	DLAT
Immunogen:	Fusion protein of human DLAT
Full name:	dihydrolipoamide S-acetyltransferase
Synonyms:	DLTA; PDCE2; PDC-E2
SwissProt:	P10515
WB Predicted band size:	69 kDa
WB Positive control:	Jurkat, A549, U251, F9, Lncap and Hela cell lysates
WB Recommended dilution:	1000-5000
IF positive control:	Hela cells
IF Recommend dilution:	150-300