購物車
幫助
021-54845833/15800441009
中文名稱：TFEB 抗原（重組蛋白）
英文名稱：TFEB Antigen (Recombinant Protein)
別 名： transcription factor EB; TCFEB; BHLHE35; ALPHATFEB
儲 存： 冷凍（-20℃）
相關類別：抗原
概 述
技術規格
|
Full name: |
transcription factor EB |
|
Synonyms: |
TCFEB; BHLHE35; ALPHATFEB |
|
Swissprot: |
P19484 |
|
Gene Accession: |
BC032448 |
|
Purity: |
>85%, as determined by Coomassie blue stained SDS-PAGE |
|
Expression system: |
Escherichia coli |
|
Tags: |
His tag C-Terminus, GST tag N-Terminus |
|
Background: |
Transcription factor that specifically recognizes and binds E-box sequences (5'-CANNTG-3'). Efficient DNA-binding requires dimerization with itself or with another MiT/TFE family member such as TFE3 or MITF. In association with TFE3, activates the expression of CD40L in T-cells, thereby playing a role in T-cell-dependent antibody responses in activated CD4+ T-cells and thymus-dependent humoral immunity. Specifically recognizes and binds the CLEAR-box sequence (5'-GTCACGTGAC-3') present in the regulatory region of many lysosomal genes, leading to activate their expression. It thereby plays a central role in expression of lysosomal genes. Acts as a positive regulator of autophagy by promoting expression of genes involved in autophagy. Specifically recognizes the gamma-E3 box, a subset of E-boxes, present in the heavy-chain immunoglobulin enhancer. Plays a role in the signal transduction processes required for normal vascularization of the placenta. Regulates lysosomal positioning in response to nutrient deprivation by promoting the expression of PIP4P1. |
