購(gòu)物車(chē)
幫助
021-54845833/15800441009
中文名稱(chēng)：PIM1抗原（重組蛋白）
英文名稱(chēng)： PIM1 Antigen (Recombinant Protein)
別 名： PIM
儲(chǔ) 存： 冷凍（-20℃）
相關(guān)類(lèi)別： 抗原
概 述：
|
Fusion protein corresponding to C terminal 228 amino acids of human PIM1 |
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Full name: |
pim-1 oncogene |
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Synonyms: |
PIM |
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Swissprot: |
P11309 |
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Gene Accession: |
BC020224 |
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Purity: |
>85%, as determined by Coomassie blue stained SDS-PAGE |
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Expression system: |
Escherichia coli |
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Tags: |
His tag C-Terminus, GST tag N-Terminus |
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Background: |
The protein encoded by this gene belongs to the Ser/Thr protein kinase family, and PIM subfamily. This gene is expressed primarily in B-lymphoid and myeloid cell lines, and is overexpressed in hematopoietic malignancies and in prostate cancer. It plays a role in signal transduction in blood cells, contributing to both cell proliferation and survival, and thus provides a selective advantage in tumorigenesis. Both the human and orthologous mouse genes have been reported to encode two isoforms (with preferential cellular localization) resulting from the use of alternative in-frame translation initiation codons, the upstream non-AUG (CUG) and downstream AUG codons. |
