購(gòu)物車
幫助
021-54845833/15800441009
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Background: |
This gene encodes a voltage-gated delayed potassium channel that is phylogenetically related to the Drosophila Shaker channel. The encoded protein has six putative transmembrane segments (S1-S6), and the loop between S5 and S6 forms the pore and contains the conserved selectivity filter motif (GYGD). The functional channel is a homotetramer. The N-terminus of the channel is associated with beta subunits that can modify the inactivation properties of the channel as well as affect expression levels. The C-terminus of the channel is complexed to a PDZ domain protein that is responsible for channel targeting. Mutations in this gene have been associated with myokymia with periodic ataxia (AEMK). |
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Applications: |
ELISA, WB, IHC |
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Name of antibody: |
KCNA1 |
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Immunogen: |
Synthetic peptide of human KCNA1 |
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Full name: |
potassium voltage-gated channel, shaker-related subfamily, member 1 (episodic ataxia with myokymia) |
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Synonyms： |
EA1, MK1, AEMK, HBK1, HUK1, MBK1, RBK1, KV1.1 |
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SwissProt: |
Q09470 |
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ELISA Recommended dilution: |
1000-5000 |
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IHC positive control: |
Human cervical cancer |
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IHC Recommend dilution: |
15-50 |
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WB Predicted band size: |
56 kDa |
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WB Positive control: |
Human brain malignant glioma tissue |
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WB Recommended dilution: |
500-2000 |
